Catalog: ZX022-025；ZX022-100
Specifications: 25ug (50ul, 0.5mg/ml),
100ug (200ul, 0.5mg/ml)
Price: contact us for price information
Product Name: Unlabeled Anti-Mouse CD11b (M1/70) Monoclonal Antibody
Description: CD11b is integrin ITGAM. Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). [provided by UniProtKB]
Specificity：Against Mouse/Human CD11b Antigen
Host：Rat
Application：Flow Cytometry, IF, IHC (For Research Purpose Only)